JAKed up phenotype of CEBPA-mutant AML
نویسندگان
چکیده
منابع مشابه
JAKed up phenotype of CEBPA-mutant AML.
The landscape of recurrent genetic events in AML has been elegantly unraveled in recent years; however, for most disease subsets this has not yet led to facile deployment of therapeutics targeting aberrant genetic events. The resulting gap in our ability to decipher genetic drivers versus our capacity to harness this knowledge for therapeutic advantage will require the integration of genotype i...
متن کاملLong-term follow-up of cytogenetically normal CEBPA-mutated AML
BACKGROUND The aim of this study was to analyze the long-term survival of AML patients with CEBPA mutations. PATIENTS AND METHODS We investigated 88 AML patients with a median age of 61 years and (1) cytogenetically normal AML (CN-AML), (2) monoallelic (moCEBPA) or biallelic (biCEBPA) CEBPA mutation, and (3) intensive induction treatment. 60/88 patients have been described previously with a s...
متن کاملCEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation
The basic leucine zipper transcription factor CCAAT/enhancer binding protein alpha (CEBPA) codes for a critical regulator during neutrophil differentiation. Aberrant expression or function of this protein contributes to the development of acute myeloid leukemia (AML). In this study, we identified two novel unrelated CEBPA target genes, the glycolytic enzyme hexokinase 3 (HK3) and the krüppel-li...
متن کاملHitting the target in IDH2 mutant AML.
A block in myeloid differentiation is a hallmark ofAML.Undifferentiated blast cells with enhanced self-renewal capabilities can accumulate in the bone marrow. When these undifferentiated cells acquire properties that provide a proliferative advantage, AML may arise. It has long been hypothesized that overcoming the differentiation block in AML would be an important component of improved treatme...
متن کاملDeficient CEBPA DNA binding function in normal karyotype AML patients is associated with favorable prognosis.
CCAAT/enhancer binding protein-α (CEBPA) mutations in acute myeloid leukemia (AML) patients with a normal karyotype (NK) confer favorable prognosis, whereas NK-AML patients per se are of intermediate risk. This suggests that blocked CEBPA function characterizes NK-AML with favorable outcome. We determined the prognostic significance of CEBPA DNA binding function by enzyme-linked immunosorbent a...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-04-709535